The FDA is repeating earlier warnings that certain statins to lower cholesterol do not mix with amiodarone, a drug prescribed to treat an irregular heartbeat. Amiodarone blocks an enzyme that breaks down some statins. This action leads to an increased risk of muscle and kidney damage called rhabdomyolysis in people taking both drugs. As a result, experts recommend that a person taking amiodarone should avoid doses over 20 mg of simvastatin or 40 mg of lovastatin. The statin drugs Lescol (fluvastatin) Pravachol (pravastatin), and Crestor (rosuvastatin) are unaffected by amiodarone.