Lipitor and Lescol work in nearly the same way to help decrease cholesterol levels in the body. Taking two medicines with similar mechanisms of action increases the risk of side effects. It is unlikely, however, that the combination caused the health conditions you mentioned. Other cholesterol-lowering drugs work in different ways and are sometimes combined with statin therapy to achieve optimal results. Keep an accurate list of all your prescription and over-the-counter medicines. When a new drug is prescribed, your doctor and pharmacist can review the list to avoid duplicate or possibly harmful therapies.