Two or more medicines may be taken at once unless the labels state otherwise. If you find it difficult to swallow multiple pills, spacing them a few minutes apart is fine, too. As mentioned above, it is a good idea to make a list of all of your drugs and supplements. Some drugs may be taken together, but they still might interact with supplements or vitamins. Many antacids and some supplements may bind to certain drugs, making them less active. Ask your pharmacist to check for potential interactions.