Experts are calling an FDA-approved vitamin therapy to improve mood a potential “paradigm shift” in the treatment of unresolved depression.
Recent research published in Innovations in Clinical Neuroscience suggests that boosting patients’ levels of the B vitamin folic acid called L-methylfolate—via tablets of the prescription medical food Deplin—helps regulate brain chemicals affecting mood.
Study data reported by Lawrence Ginsberg, MD, show that patients taking Deplin in addition to an antidepressant improved 2.5 times more often than those taking an antidepressant alone. Patients on the combined therapy also achieved results more quickly.
Depression, a chronic, recurrent disease, is one of the nation’s most common ailments, affecting more than 18 million people in the United States.
And new treatment options are desperately needed. Nearly 70 percent of patients with major depression won’t improve with initial monotherapy, according to the landmark Sequenced Treatment Alternatives to Relieve Depression study.
Scientists have long suspected a link between a deficiency of bioactive folate and depression. L-methylfolate was chosen for the study because of its ability to cross the blood-brain barrier, its bioavailability, and its safety benefits compared to folic acid and other synthetic folates.
Have you tried Deplin? Did it work? Let us know!