When stressed, the body activates a tiny region in the brain called the hypothalamus that stimulates the suprarenal glands (red arrows) to release a surge of hormones, including adrenaline and cortisol (yellow arrows). Although the body’s stress-response system is typically self-regulating, returning to normal after a perceived threat passes, constant stress can seriously disrupt almost all the body’s processes, putting one at risk of a variety of serious health issues. Image © BSIP/Photo Researchers, Inc.