Your Health Checkup: Drugs and Daily Activity

“Your Health Checkup” is our online column by Dr. Douglas Zipes, an internationally acclaimed cardiologist, professor, author, inventor, and authority on pacing and electrophysiology. Dr. Zipes is also a contributor to The Saturday Evening Post print magazine. Subscribe to receive thoughtful articles, new fiction, health and wellness advice, and gems from our archive. 

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Yesterday morning while exercising as usual, I inflamed an old biceps tendonitis that triggered pain whenever I moved my arm. I needed treatment with a nonsteroidal anti-inflammatory drug (NSAID).

While researching which drug to take, I came across an interesting article stating that administering NSAIDs during the daily activity period, i.e., in the morning for most people, resulted in better pain relief and healing than taking the NSAID in the evening prior to retiring.

The reason appears to be based on the body’s circadian rhythm; that is, the cyclical 24-hour period of human biological activity.

The mediators of most wound healing and connective tissue formation occur during the resting phase of the day, while pain and inflammation occur during the active period of the day. It follows that one would want the NSAID impact to occur during the period of pain and inflammation and not during the wound healing phase, hence the recommendation for taking the drug in the morning.

The opposite is true for blood pressure control. As I have written previously, the time to take blood pressure medication is in the evening, not the morning. Nighttime blood pressure is a stronger risk predictor of cardiovascular disease than is daytime blood pressure, and blood pressure control at night works better than control in the morning.

So, take NSAIDs in the morning and blood pressure medicines in the evening.

But here’s a drug you probably should avoid, if possible: azithromycin.

Azithromycin (AZ), an antibiotic in the same class as erythromycin, is one of the most commonly prescribed antibiotics in the U.S. despite an increased risk of cardiovascular death noted in some studies, perhaps related to changes in heart rhythm A recent study of almost 8 million antibiotic exposures (22 percent AZ; 78 percent amoxicillin) from January 1, 1998 to December 31, 2014, in patients with a mean age 51 years, and 62 percent women, found that AZ was associated with about a twofold increased risk of death during the first five days of exposure compared with amoxicillin. I would recommend that AZ be used with caution, particularly in patients who might be at increased risk, such as those with underlying heart disease, electrolyte abnormalities, or those taking other drugs that might affect the heart rhythm in a similar fashion.

Featured image: David Tonelson /

Managing Pain Without Pills

During the summer of 2017, my dear friend Colin Hickey needed to undergo surgery. He had managed to tear the labrum of each hip (a cartilage ring around the hip socket), due to a combination of his active lifestyle of hiking, playing tennis, and dancing, plus a structural deformity. The surgeon needed to fix both sides, so he would operate on one side first and then do the other a couple of months later.

This sort of surgery is difficult to describe in terms of its “seriousness.” On the one hand, it’s minimally invasive. The surgeon is able to do the work with only very small incisions, so the outward appearance is of a fairly minor surgery. Once inside, however, he would have to repair the torn cartilage and carve down some excess bone to prevent the sort of friction that caused the tear in the first place. This explains why people who undergo this surgery have months of physical therapy and recovery, after weeks of extremely limited mobility.

After his first surgery, I visited Colin at his apartment, and since I had undergone multiple surgeries two years earlier after a motorcycle accident, we swapped “war stories.” He was in pretty rough shape, able to move only very little, and was confined to his bed for most of the day. He looked pained but also completely alert. I asked him about his pain and meds.

“Yeah, they gave me a bottle of pills, but I don’t want ’em,” he replied. He knew of my struggle with painkillers — when I went through months of excruciating suffering caused by opioid dependence  — and he looked at me sympathetically. “Obviously I know the risks; but I also just don’t think I need them. It hurts, and it’ll hurt for a while. But the first days were the worst, and I made it through. So I don’t think they’re necessary.”

As usual with Colin, who is one of the most focused, thoughtful, straight-up toughest people I know, I was impressed. “So you didn’t take any of the pills? At all?”

“Not a one,” he replied.

Colin has always been something of an ascetic. He doesn’t need stuff, and he isn’t a huge fan of medicine. And while he would have, I think, taken the pills if he really thought he needed them, he just wasn’t afraid of some pain, and he was willing to be uncomfortable and work hard.

I’ve always admired him for his dedication to a philosophically rigorous life, but I admired him even more after that day. There wouldn’t have been anything wrong with his taking the pills, but he didn’t need them. And instead of using them anyway, to drive his pain down from manageable to zero, he just stuck it out. When he went in for the second surgery some weeks later, he told his surgeon that he hadn’t used any of the pills, so he didn’t need a new prescription.

And he was right. When the summer was over, and both hips had been fixed, he was pushing his way through physical therapy and still had an untouched bottle of 60 Percocet.

Nothing about my admiration for Colin should indicate that I think all torn labrum surgeries should be ­performed without prescribing opioids for recovery. If you have had that surgery and you took some of the pills, I get it; I probably would have too. What I love about Colin’s story, rather, is that it highlights the degree to which some pain can simply be dealt with. Not all of it needs to be, but some of it can be.

“Yeah, they gave me a bottle of pills, but I don’t want ’em,” he replied.

Life hurts — quite a lot for some of us — but not all of those pains require pharmacological intervention. And importantly, our expectations can really affect how reasonable that suggestion seems. Part of why Colin was able to make it through that summer, I think, is because he doesn’t expect life to be pain-free, and he’s willing to put up with quite a lot. Perhaps more than should be expected of any of us. But it’s important to reflect on what we can do in order to think carefully about what we should do.

After my accident in 2015, trauma caught me by surprise, and when I found myself in hospitals for weeks, on morphine and fentanyl drips, popping oxycodone, I hadn’t prepared myself at all. It was all new and terrifying. I had one goal: avoid the pain. And only in retrospect can I realize that I carried that goal much too far forward into my recovery.

I wish someone had prepared me for the pain — told me that I would hurt and that it would be scary, but that I didn’t have to let elimination of pain become my sole priority. In short, I wish I had been mentally ready to balance the need for pain relief against the risks and costs of medication. This leads me to think that one of our major goals for rethinking how we deal with pain is not a goal for physicians; it’s a goal for the rest of us.

In many places around the world, but especially in America, we live in a “pill for every pain” culture. You have a headache? There’s a pill for that. Sprained your ankle? Pill for that. Ongoing back pain? Yup, you guessed it. Our over-the-counter medications already capitalize on this culture, selling us acet­aminophen, ibuprofen, and aspirin by the buckets. It’s no surprise, then, that prescription pharmaceutical companies jumped on board as well. The basic strategy behind Purdue’s marketing campaign in the 1990s and early 2000s was that OxyContin was effective (stronger than morphine, and lasts 12 hours!) and safe (less than 1 percent of patients develop an addiction!). So why restrict its use to cancer or palliative care? OxyContin is the pill for moderate to severe pain — the pill, that is, for nearly every pain.

The unfortunate fact, however, is that medications have side effects. The effects of opioids can be particularly devastating, but that certainly doesn’t make it the case that all other painkillers are perfectly safe. Acetaminophen must be carefully limited in dosing to avoid causing liver damage, NSAIDs like ibuprofen and celecoxib raise one’s risk of heart attack and stroke.

This consideration of trade-offs is especially difficult for treating chronic pain. As we now know, opioids should not be considered first-line treatment for chronic pain, as they are risky and may well be no more effective than non-opioid therapies. However, most physicians will also warn patients that a lifetime of any pain medication can be dangerous, given the side effects listed above. Determining how to proceed is truly difficult. Sometimes there are alternative interventions that can be considered, such as injections, nerve blocks, or surgery. And sometimes it is completely unclear what will be best for a particular patient.

Not all treatments for pain involve a pill (or some other medical procedure). A truly surprising amount of scientific data supports what we might think of as “lifestyle” therapies, or as some people call it: self-care.

There are many such strategies, supported by varying degrees of scientific evidence, and more research is being conducted all the time. Looking at just some of the most common suggestions: Exercise, yoga, and massage have all been shown to be beneficial for dealing with pain. And really, this shouldn’t be all that surprising. After all, doing these things amounts to taking care of one’s body, which can strengthen and heal weak and damaged tissue.

I wish someone had prepared for the pain — told me that I would hurt and that it would be scary, but that I didn’t have to let elimination of pain become my sole priority.

Additionally, cognitive-behavioral therapy (CBT) — a form of psychotherapy that focuses on altering unhelpful cognitive patterns and behavior — has been shown to be effective for treating certain forms of chronic pain. Despite this evidence base, however, many people find such a suggestion offensive: “What? So you think this is all in my head? You think my pain isn’t real?”

That pain can be treated with CBT, however, implies nothing of the sort. Chronic pain is often what’s called “maladaptive pain,” which means it no longer signals tissue damage or injury. Whereas acute pain serves as an alert that one’s body is at risk, that same pain can transition into chronic pain that no longer serves that function.

It’s maladaptive — rather than adaptive — pain that causes suffering but which plays no productive health role. The evidence that CBT can successfully treat chronic pain suggests that therapy can help the brain and nervous system to correct this dysfunction. By pursuing psychological health, one can simultaneously promote pain relief.

Acupuncture has also been shown to be effective in treating chronic pain. And research is being conducted into all sorts of lifestyle interventions, ranging from mindfulness meditation to qigong and tai chi. In short, the evidence is mounting that changing one’s lifestyle can constitute genuine pain therapy. None of them is a magic bullet (sadly, we don’t have one of those), but they are genuine treatments.

Look, it’s certainly not the case that self-care is magic and will replace our need for powerful opioid medications. Some pain is devastating and life-limiting, and sometimes that pain responds well to opioids. I am most certainly not recommending that we all just get up after an injury and “rub some dirt in it.” That’s not the answer, and not my suggestion.

But we can be part of an important culture change. We can stop demanding from our doctors a pill for every pain, and we can try to take seriously the nonpharmacological treatments they suggest. We can ask whether 60 pills is really necessary, or whether just a few might do.

In short, each one of us can make a difference. Not by trying to eliminate opioids from pain medicine but by formulating an attitude and a set of expectations that help our doctors use those powerful tools responsibly.

We all need to foster a different relationship with pain and develop a different understanding of medicine — what it does and doesn’t owe us, and what we should expect from our doctors. We also need to understand addiction and expand our circle of empathy, demanding that our elected officials do the same.

Medicine can be improved and public health interventions can be introduced, but they won’t be unless we demand them.

“My Mind and Body Had Been Shattered”

While recovering from a motorcycle accident, I became dependent on opioids. Quitting was the hardest thing I had ever done

By Travis Rieder

An infant's hand in a baby's hand.

It was as if I had a fire in my core, and it would spread to my limbs, causing them to twitch and kick. If I tried consciously to lie still in order to sleep, my legs would constantly move, keeping me from getting any rest whatsoever. And if I tried with all my might to hold my legs in one place, it was like electricity built up inside my muscles, threatening explosion if I didn’t release it. Eventually, no matter how hard I tried, I would flex or kick and eventually thrash about.

When the darkness swirled in, my mind went to scary places. I began to genuinely mourn what had happened to me, and also to believe that it meant the end of the happy life I had known before. As the days dragged on, I became convinced that I would never recover — not from the accident, not from the withdrawal. My mind and body had been shattered, and it was like believing in a fairy tale to think that anyone could recover from where I was. Surely there is a point beyond which one simply doesn’t bounce back, and surely I had passed it.

Perhaps if my doctors had told me what to expect with opioid withdrawal, I could have intellectually prepared myself for what I had to do in order to resist. I could have reminded myself that I knew why this was happening and that I would get through it. But I had no preparation, and no help, so I let the darkness steer me. I thought that I had special insight into just how damaged I was, and the answer was: severely damaged. Too far gone to be salvaged. A good portion of each day, then, was spent sobbing and wondering what I would do if this was my new life. For a while at least, the darkness was intermittent; after crying for a bit, I would start to pull through it, and especially when my wife Sadiye was there to talk to me, I could start to right the ship of my emotions. But as the days wore on, the darkness came more often and stayed longer, putting more and more pressure on Sadiye to be there to pull me out of a tailspin.

Our lives settled into a very tight, very hard, very stressful pattern. Sadiye would spend time with me in the morning (indeed, she often woke up in the middle of the night to come check on me, and to see if I was sleeping at all). Then she would leave for work, dropping our toddler Sinem off at day care, and I would try to make it through the morning without a depressive episode. I knew that if I could make it until close to noon, she would come back home during her lunch break, and I focused on that whenever the morning got hard.

The afternoons were harder. They seemed to stretch on much longer, and I quickly got to the point where I rarely made it through an afternoon without breaking down in tears. I’d always know it was coming, and I tried to fight it. The game was distraction and a desperate hope for real rest. If I could keep my brain occupied — or, even better, if I could get in a nap — I could sometimes make it through the afternoon without a call to Sadiye to talk me down from whatever mental precipice I found myself on that day.

My beautiful, wonderful baby daughter gets left out of a lot of this story, and that’s really part of the pain; I simply wasn’t present, so I barely remember her being there at all. I know that Sadiye was somehow managing to handle childcare while also caring for me and running the house. And I vaguely remember Sinem occasionally crawling on me on the couch while Sadiye sat apprehensively on the ottoman just inches away, watching so that she could jump up and grab her if she got too close to my foot or the surgical site on my thigh. But most of what I remember is solitude and pain.

I do, however, remember one particular day, as it changed my view of what my one-and-a-half-year-old daughter was capable of.

I had made it the whole day through late afternoon without crying, and without the depression crashing in. I had dared to hope that this might mean I was turning a corner and that maybe I was going to get some of my life back. And then, around four or five o’clock, I felt the telltale welling in my chest and the darkness circling. The feeling immediately caused panic, and then despair. Sadiye picked up on the first ring, and I blurted out through sobs, “I almost made it today. Oh God, I’m so sorry. I’m so sorry I had to call you. I started to think I could survive this. But I can’t. This will never get better. I’m so broken, baby … I’m just so broken. How can a body possibly recover from this?”

She was already driving home. “You will survive this,” she said. “Your hormones and your brain, they’re betraying you. But it will get better. Now just hold on. I’m about to pick up Baby Girl, and then we’ll be home to take care of you.” I said okay and hung up.

When the car pulled up outside the front window, right behind my spot on the couch, I tried to stop crying, as I always did my best not to let Sinem see me like that. But it was no use. The harder I tried, the more explosive the sobs became, and I eventually just gave up.

Sinem tends to enter the house like a freight train, and this day was no exception. When the door opened, she burst into the living room, singing at the top of her lungs. Until she saw me. She stopped babbling mid-sound and mid-step, and her face turned serious. As she slowly walked over to where I was lying on the couch, I just cried to her. “I’m so sorry, Baby Girl. Oh God, I’m so sorry. I hope you won’t remember this.”

She didn’t seem upset, though. She seemed in control. I was lying on my side on the couch, and so I was about eye level with her. She walked until her face was inches from mine, examining me intently with the deep, dark brown eyes that she got from her mom, and she asked, “Baba crying?”

“Yes, Baba crying,” I told her. “Baba hurts, but it will be okay.” I didn’t believe it, but I was trying my best to be strong for my daughter.

And then she did something that I didn’t understand and will never forget. She put her tiny little hands on my cheeks and held my face firmly while she looked directly at me. And then she kissed my eyes, one at a time. I had never seen her do anything like that before, and I could hardly believe it. Maybe she had learned that at day care; maybe one of her helpers had kissed her eyes after she fell down one time. Or maybe it was just an incredible, empathetic intuition by my little girl. Whatever the explanation, I grabbed her and hugged her as tightly as I ever have, and I told her that she had just helped Daddy get through one more night.

From In Pain: A Bioethicist’s Personal Struggle with Opioids by Travis Rieder. Copyright © 2019 by Travis Rieder. Reprinted by permission of Harper, an imprint of HarperCollins Publishers

Featured image: Shutterstock

Pain Management in Pets: An Owner’s Guide

There are many parallels between people and pets when it comes to anticipating and addressing pain associated with surgical procedures.

Dr. Jordyn Boesch, a board-certified veterinary anesthesiologist at the University of Illinois Veterinary Teaching Hospital in Urbana, urges owners to talk with their veterinarian about the medications that will be used in their pets to control surgical pain and to work closely with their veterinarian to manage pain for optimal health outcomes.

“It is now accepted, thanks to a very large body of scientific evidence, that animals experience pain in much the same way that human beings do,” Dr. Boesch says.

While procedures like a spay, castration, tooth extraction, or lump biopsy may be necessary for the health of your pet, these procedures will cause pain if adequate pain medication is not administered. Pain medications are more effective when they are given both before and after such procedures.

Controlling pain is important not just for ethical reasons, but because studies show it can also speed your pet’s recovery.

“Pain causes the body to release a wide variety of stress hormones that interfere with tissue healing,” explains Dr. Boesch, “so decreasing stress can lead to faster healing.”

Dr. Boesch advises pet owners to discuss the pain management plan with their veterinarian before any surgical procedure and to ask specific questions: What kind of pain medication will be administered, and at what points in the procedure? What are possible side effects or risks of those medications? What are the instructions for administering any pain medication at home after the procedure? What signs of pain should you watch for at home?

Because the signs of pain may not be easily detected, it is important to consult your veterinarian for advice on general signs of pain as well as signs that may be specific to your pet’s species or the procedure performed. A pet in pain may simply appear more subdued, may stop eating or drinking, or may not want to engage in favorite activities. Cats may hide, stop grooming, or eliminate outside the litter box. The pet may look at or lick an incision site or “guard” the area that is painful. Unusual behaviors should not be ignored or attributed simply to the stress of visiting the vet’s office.

Some species may not show any signs of pain at all.

“Farm animals such as horses and cattle, as well as birds and small mammals such as rabbits, indicate pain even more subtly because, as prey species, they have evolved to hide signs of pain from predators,” says Dr. Boesch.

Just as in human medicine, veterinary medicine makes use of a range of pain medications suited to various conditions. Sometimes using more than one pain medication together, such as morphine (or related drugs) plus an anti-inflammatory drug, is needed and is more effective than either one used alone. And sometimes, other non-drug treatments such as physical therapy or icing an incision can help tremendously too.

Dr. Boesch stresses the importance of giving pets only the medications and doses indicated by a veterinarian.

“Pet owners should never take their animal’s pain management into their own hands,” she says. “Giving an over-the-counter human pain medication to a cat, for example, could kill the cat. Owners must consult their veterinarian before giving their pet any medicine or supplement.”

If you have any questions about pain management in your pet, please consult your local veterinarian.

Julia Disney is an Information Specialist at University of Illinois’ College of Veterinary Medicine.